42 Porto is based in the historical center of the city, at Aliados, well served by public transportation, close to the City Hall and the subway station of Trindade. This is an area of easy access, well served with public transportation, and a vast variety of restaurants and services.

The campus of 42 Porto occupies the 3rd floor of what previously was the Palácio dos Correios, a building shared with the offices of Critical Techworks, one of the partners of 42 Porto. Besides the working space, 42 Porto shares with Critical Techworks a lunching area and a rooftop.